Packers at 49ers (-3.5) Betting Preview

Green Bay Packers at San Francisco 49ers (-4)
Sunday 9/26, 8:20 p.m. ET

Three things you need to know before betting on Packers-49ers:

1. The 49ers have gotten the best of this head-to-head series in recent years, going 6-3 straight-up and 6-2-1 against the spread when facing the Packers since the start of the 2012 season. That includes a record of 4-0 both straight-up and against the spread in games San Francisco has played as a home favorite over Green Bay. The 49ers have outscored the Packers by an average margin of 16.5 points over those four meetings.

2. This marks the ninth time since the start of the 2019 season that Green Bay has been getting points and the eighth time that the Packers have been getting points against an NFC opponent. Two of those previous seven times have been in San Francisco, with Green Bay losing 37-8 as a 3-point underdog in a Sunday Night Football meeting in November 2019 and 37-20 as an 8-point underdog in the NFC Championship Game in January 2020. In the other games that the Packers have been getting points from an NFC opponent since the start of 2019, Green Bay has pulled off the upset all five times, winning by an average margin of 9.2 points over the five games.

3. The 49ers are one of only three NFC teams against which Green Bay’s Aaron Rodgers has a losing record in his career (the Cardinals and Buccaneers are the other two). The Packers’ 5-6 record against San Francisco with Rodgers under center can hardly be blamed on the quarterback’s performance, however, as Rodgers has thrown 23 touchdown passes with only five interceptions while averaging more than 280 passing yards over the 11 games. Eight of the 11 games Rodgers has played against the 49ers have gone Over the total, as an average of more than 52 total points have been scored over the 11 games.