Cardinals at Browns Betting Preview

Arizona Cardinals at Cleveland Browns
Sunday 10/17, 4:05 p.m. ET

Three things you need to know before betting on Cardinals-Browns:

1. Only the Bills enter Week 6 with a larger yards-per-play differential than the Browns, who are gaining an average of 6.5 yards per offensive play while allowing an average of 5.4 yards per defensive play through the 2021 season’s first five games. NFL home favorites that are outgaining opponents by an average margin of at least 0.75 yards per play, however, are just 12-20 straight-up and 5-25-2 against the spread since the start of the 2017 season when coming off a three-game stretch in which they gained an average of 400 or more total yards. Such teams have been outscored by an average of 2 points over those 32 games despite having been favored by an average spread of 7 points.

2. Cleveland comes into this one having gone 6-0 both straight-up and against the spread when facing an NFC opponent since the start of last season. The Browns have outscored NFC teams by an average margin of 11.8 points in those six games. Arizona, meanwhile, has gone 4-2 straight-up and 5-1 against the spread on the road when facing an AFC opponent since the start of the 2019 season.

3. The Cardinals last played on the road two Sundays ago, when they beat the Rams 37-20 as a 3.5-point road underdog in a game that went over its total of 54 points when Rams receiver Robert Woods scored a garbage-time touchdown with 74 seconds remaining in the fourth quarter. Prior to that, the Under had been 9-0-1 in Arizona road games since the start of last season.